Wolf-Karsten Hofmann Selected Research

Pre-B Cell Receptors

8/2009	Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.
9/2005	Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.
6/2005	Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.
3/2004	The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells.

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Wolf-Karsten Hofmann Research Topics

Disease

39	Neoplasms (Cancer) 08/2022 - 01/2004
24	Leukemia 01/2022 - 10/2003
22	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 08/2008
18	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 08/2022 - 07/2003
16	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018 - 07/2003
14	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2021 - 07/2006
9	Systemic Mastocytosis 01/2022 - 08/2010
8	Eosinophilia 01/2022 - 08/2011
8	Philadelphia Chromosome 01/2018 - 07/2003
7	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 08/2012
7	Acute Promyelocytic Leukemia 12/2020 - 08/2008
7	Aspergillosis 01/2018 - 07/2012
6	Infections 01/2022 - 01/2005
5	Aneuploidy (Aneuploid) 05/2020 - 01/2012
5	Blast Crisis (Blast Phase) 09/2017 - 10/2003
4	Carcinogenesis 01/2022 - 12/2010
4	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2013 - 06/2009
3	Breast Neoplasms (Breast Cancer) 06/2022 - 01/2018
3	Inflammation (Inflammations) 01/2022 - 01/2020
3	Chromosome Aberrations (Chromosome Abnormalities) 05/2021 - 08/2008
3	Iron Overload 01/2021 - 05/2018
3	Genomic Instability 05/2020 - 01/2012
3	Disease Progression 05/2020 - 02/2015
3	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 03/2013 - 03/2004
3	Carcinoma (Carcinomatosis) 01/2012 - 12/2010
3	Lymphoma (Lymphomas) 10/2007 - 01/2006
2	Chromosomal Instability (Chromosome Stability) 01/2021 - 12/2010
2	Primary Myelofibrosis (Myelosclerosis) 12/2020 - 04/2011
2	Hemorrhage 12/2020 - 01/2018
2	Sepsis (Septicemia) 01/2020 - 02/2010
2	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 10/2019 - 01/2017
2	Myocardial Infarction 01/2018 - 10/2004
2	Pancytopenia 03/2017 - 08/2011
2	Invasive Pulmonary Aspergillosis 02/2016 - 02/2016
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2015 - 02/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2014 - 07/2011
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 07/2014 - 02/2003
2	Residual Neoplasm 03/2013 - 08/2011
2	Brain Neoplasms (Brain Tumor) 01/2003 - 11/2002
1	COVID-19 08/2022
1	Cardiotoxicity 06/2022

Drug/Important Bio-Agent (IBA)

20	Imatinib Mesylate (Gleevec)FDA Link 02/2020 - 07/2003
11	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2004
10	Phosphotransferases (Kinase)IBA 02/2020 - 03/2004
9	DNA (Deoxyribonucleic Acid)IBA 05/2021 - 08/2008
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2010
7	Lenalidomide (CC 5013)FDA Link 06/2021 - 08/2008
7	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 08/2009
6	SeparaseIBA 05/2020 - 01/2012
6	Pharmaceutical PreparationsIBA 08/2018 - 01/2006
5	Tryptases (Tryptase)IBA 01/2022 - 09/2015
4	ruxolitinibIBA 08/2022 - 03/2013
4	nilotinib FDA Link 01/2020 - 08/2010
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2018 - 08/2008
4	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 09/2017 - 09/2005
4	Pre-B Cell ReceptorsIBA 08/2009 - 03/2004
3	midostaurinIBA 01/2022 - 01/2017
3	IronIBA 01/2021 - 10/2015
3	AzolesIBA 01/2018 - 07/2012
3	Messenger RNA (mRNA)IBA 09/2014 - 01/2003
3	Biological ProductsIBA 09/2014 - 04/2006
2	Rituximab (Mabthera)FDA Link 08/2022 - 07/2014
2	AdiponectinIBA 01/2022 - 03/2009
2	eltrombopag FDA Link 01/2022 - 12/2014
2	Conditioned Culture MediaIBA 05/2021 - 01/2021
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021 - 01/2013
2	Dasatinib (BMS 354825)FDA Link 01/2020 - 08/2010
2	Hemoglobins (Hemoglobin)IBA 11/2019 - 09/2015
2	Deferasirox FDA Link 08/2018 - 10/2015
2	Cytarabine (Cytosar-U)FDA LinkGeneric 02/2018 - 01/2014
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 11/2017 - 01/2017
2	galactomannanIBA 02/2016 - 08/2012
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 11/2015 - 01/2012
2	MicroRNAs (MicroRNA)IBA 04/2015 - 02/2011
2	Peptides (Polypeptides)IBA 01/2015 - 10/2011
2	SteroidsIBA 07/2014 - 07/2011
2	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2014 - 01/2013
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2013 - 03/2011
2	Proto-Oncogene Proteins c-etsIBA 04/2013 - 02/2011
2	Transcription Factors (Transcription Factor)IBA 01/2013 - 01/2005
2	Insulin-Like Growth Factor Binding ProteinsIBA 12/2011 - 01/2011
2	Sunitinib (Sutent)FDA Link 08/2011 - 08/2010
2	Sorafenib (BAY 43-9006)FDA Link 08/2011 - 08/2010
2	SurvivinIBA 08/2011 - 06/2007
2	Azacitidine (5 Azacytidine)FDA Link 11/2010 - 09/2010
2	src-Family KinasesIBA 08/2009 - 10/2007
2	Protein Isoforms (Isoforms)IBA 06/2009 - 06/2007
1	2019-nCoV Vaccine mRNA-1273IBA 08/2022
1	BNT162 VaccineIBA 08/2022
1	SARS-CoV-2 spike proteinIBA 08/2022
1	Cladribine FDA LinkGeneric 01/2022

Therapy/Procedure

25	Therapeutics 06/2022 - 07/2003
14	Drug Therapy (Chemotherapy) 02/2018 - 02/2003
10	Stem Cell Transplantation 01/2018 - 06/2010
3	Transplantation 05/2018 - 10/2004
3	Aftercare (After-Treatment) 07/2011 - 07/2003
2	Catheters 01/2022 - 01/2020
2	Central Venous Catheters 01/2022 - 01/2014
2	Cell Transplantation 01/2020 - 05/2018
1	Premedication 01/2022